Bioidentical vs. Synthetic HRT: What’s the Difference?
When it comes to hormone replacement therapy (HRT), understanding your options is key!
Here’s a quick breakdown:
Bioidentical HRT
Derived from plant sources
Chemically identical to human hormones
Can be custom-compounded or FDA-approved
Synthetic HRT
Lab-created, often derived from animal sources
Not structurally identical to human hormones
Includes well-known options like Premarin & Provera
Which is better? At Medical Health & Wellness, wI prescribe mainly Bioidentical HRT as it is typically the safest way to replace hormones. It depends on your needs, health history, and how your body responds.
Bioidentical Progesterone
Bioidentical progesterone is often used in hormone replacement therapy (HRT) to help balance hormones, especially during menopause, perimenopause, or for certain hormonal imbalances. Unlike synthetic progestins, bioidentical progesterone is structurally identical to the progesterone naturally produced by the body.
Key Benefits:
There's a range of key potential health benefits, including supporting hormonal balance by easing symptoms of estrogen dominance like bloating and mood swings, and improving sleep by calming the brain. It can also boost mood and reduce anxiety by supporting relaxation, protect bone health by aiding in bone formation, and contribute to heart health by helping to maintain healthy blood pressure. Additionally, some research indicates it may support brain function and potentially reduce the risk of cognitive decline. For women experiencing menopause, progesterone can help alleviate symptoms such as hot flashes and night sweats.
Bioidentical progesterone is considered a more natural alternative to synthetic progestins, as it's metabolized similarly to the body's own hormone and may result in fewer side effects.
Always consult a healthcare provider before starting bioidentical progesterone to determine the right dosage and form (oral, topical, or vaginal).
Bioidentical Estrogen Therapy
Bioidentical estrogen therapy is often used in hormone replacement therapy (HRT) to help manage symptoms of menopause, perimenopause, or estrogen deficiency. Unlike synthetic estrogens, bioidentical estrogen is chemically identical to the estrogen naturally produced by the body.
Key Benefits:
Estrogen offers a wide array of benefits, particularly for women experiencing hormonal changes. It effectively reduces hot flashes and night sweats by regulating body temperature, while also supporting heart health by maintaining healthy cholesterol and blood vessel function. Furthermore, estrogen plays a crucial role in protecting bone health, reducing the risk of osteoporosis and fractures. It may also support cognitive function, potentially lowering the risk of cognitive decline and dementia. Additionally, estrogen improves vaginal and urinary health, alleviating dryness and discomfort. It enhances sleep quality, boosts mood and mental well-being by supporting neurotransmitters, and contributes to skin and hair health through collagen production. Finally, it aids in maintaining muscle mass and supporting a healthy metabolism.
Bioidentical estrogen is available in different forms (patches, creams, gels, pills, or vaginal applications). It’s often combined with bioidentical progesterone to balance hormone levels safely.
As with any medication, you should consult a healthcare provider to determine the best approach based on your individual needs and risks. Schedule a Telehealth consultation for a comprehensive assessment and get your hormone levels checked to find the safest and most effective option for YOU!

Elizabeth Murphy
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